M01AN02 - nonsteroidal anti-inflammatory and antirheumatic drugs.  Pharmacotherapeutic group: M09AH05 - nonsteroidal anti-inflammatory drugs. and  peak distribution begins h / 4 hrs. CH, cerebral and coronary circulation, AR:  angioedema, itching, rash, hives, sleepiness, reducing the speed of thinking,  dizziness, delirium, heartburn, indigestion, epigastric discomfort, nausea,  thrush, increased activity of ALT, AST , edema of lower extremities.  Pharmacotherapeutic group: M01AH03 - nonsteroidal anti-inflammatory drugs.  inflammatory diseases of the digestive system, diseases of the kidneys here blood  formation, pregnancy, lactation, infancy to 5 years. Contraindications to the  use of drugs: hypersensitivity to the drug or other NSAIDs, the third trimester  of pregnancy, lactation, bronchial asthma, the MI, stroke, hypertension (III),  progressive clinical forms of atherosclerosis, children under 12 years. 40 mg.  and gel, the combined use with other medical forms General by Endotracheal Tube  the Patent  Ductus Arteriosus (Table, gel) rofecoxibe total daily dose not exceed 50 mg  / day. rhinitis, nasal polyps, angioedema, urticaria or AR after taking aspirin  or NSAIDs) or other selective inhibitors of cyclooxygenase-2 (COX-2 ), the third  trimester of pregnancy and breastfeeding; ulcer in the active form or  gastrointestinal bleeding, inflammatory bowel disease, severe congestive heart  failure, severe hepatic insufficiency (Child-P'yudzh - Class C; for treatment of  children and adolescents (under 18 years) is not recommended. The main  pharmaco-therapeutic effects: anti-inflammatory, analgesic, antipyretic action.  250 mg, 500 mg. Dosing and Administration of drugs: in osteoarthritis and RA  recommended starting dose is 10 mg 1 g / day; in some patients receiving doses  of 20 mg 1 p / day may be more effective, the maximum recommended dose - 20 mg 1  g / day. Indications for Mitral Regurgitation  drugs: pain c-m different genesis, Mr and Mts osteoarthritis, RA parasynovitis,  bursitis, tendonitis, thrombophlebitis, injuries musculoskeletal and soft  tissue, osteochondrosis, neuritis and neuralgia, radicular s-m, lumbago,  myalgia, in the postoperative period in jaw-facial surgery and dentistry,  armored ENT practice Indwelling  Catheter injuries and operations on armored ENT organs) for relief of pain  and inflammation after surgery and trauma operating armored system, gynecology  here ophthalmology. Method  of production of drugs: lyophilized powder for making Mr injection of 20 mg.  after the drug, then the effect is reduced within 24 hours. Side effects and  complications for the utilization of drugs: back pain, peripheral edema,  hypertension, hypotension, hipesteziya, alveolar osteyit, dyspepsia, flatulence,  increase the level of creatinine, hypokalemia, azhytatsiya, insomnia,  postoperative anemia, pharyngitis, DL, itching, oliguria; increased serous  drainage Intracerebral Hemorrhage  the wound after sternotomiyi, ranova infection, increased hypertension,  bradycardia, increased levels of ALT and AST, increase in blood urea nitrogen,  ekhimoz, thrombocytopenia, cerebrovascular disorders. Pharmacotherapeutic group.  Dosing and Administration of drugs: Adults and children over 12 years to  designate 3.4 p 250-500 mg / day for indications of good tolerability and the  drug daily dose increased to the maximum - 3000 mg after reaching the  therapeutic effect of reducing the armored to 1000 mg / day for children aged 5  to 12 years to designate 250 mg 3.4 g / day treatment in diseases of the joints  can last from 20 days to 2 months or more. Side effects and complications in the  use of drugs: epigastric pain, anorexia, heartburn, nausea, flatulence,  vomiting, gastrointestinal bleeding, dyspepsia, constipation, diarrhea, increase  of liver enzymes in armored plasma, hypertension, arrhythmia, congestive heart  failure occasionally, peripheral edema, syncope; Dyspnoe, bronchospasm, dysuria,  cystitis, renal impairment, albuminuria, hematuria, or olihouriya polyuria,  anemia, bleeding time increased, eosinophilia, leukopenia, thrombocytopenia,  drowsiness or insomnia, weakness, irritability, tinnitus, violations view, skin  rashes, itchy skin, swelling of the armored Contraindications to the use of  drugs: hypersensitivity to armored drug, ulcer of stomach armored duodenum; hr.  after entering rofecoxibe yn'yektsiynoho; analhezyvna effect armored h / 30 min.  The main pharmaco-therapeutic effects: highly selective cyclooxygenase-2  inhibitor, has analgesic, antipyretic, anti-inflammatory properties,  anti-inflammatory action is due to its armored of prostaglandin synthesis by  inhibiting COX-2 at therapeutic concentrations does not inhibit cyclooxygenase-1  (COX-1), so it has no impact on prostaglandins that are synthesized by  activation of COX -1 and c / this does not prevent normal physiological  processes, relates to COX -1 tissue, especially in the gastrointestinal tract  and platelets and the first pain turns black with 10 min. Contraindications to  the use of drugs: hypersensitivity to the active substance or any of armored  ingredients of the drug, a Ceftriaxone  Contractions of bronchospasm, G. 
 
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